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TtGG Laboratory Curriculum

Teaching the Genome Generation™ (TtGG) empowers high school teachers to enhance genomics education with resources on DNA ethics, methods, and bioinformatics.

Module Description

Teaching the Genome Generation™ (TtGG) equips high school teachers with the knowledge, strategies, and resources to enhance student learning in genomics and personalized medicine. The program covers:

1. Ethics involved in DNA testing (both in the classroom and the community)

2. Methods involved in isolating, amplifying, and detecting DNA

3. Bioinformatic methods utilized in analyzing DNA, RNA, and amino acid sequences.

In collaboration with Harvard Medical School's Personal Genetics Education Project (pgEd), TtGG provides bioethics lessons and resources that support teachers in implementing the laboratory portion of the TtGG curriculum. The lab exercises use human genes, helping students connect with the material and take ownership of their results.

For bioinformatics lessons, check out our Cancer Genetics, Sequence Comparison, Variation in the Genome, and Genetic Ancestry or our Bioinformatics Exercises.

Learning Objectives

  1. Properly use laboratory equipment to perform modern laboratory techniques.
  2. Perform genotyping assays for several common human alleles to demonstrate human genetic variation.
  3. Interpret DNA gels and/or DNA sequencing traces to identify genotypes for several common human variants.

NGSS Alignments

Disciplinary Core Ideas
  • LS1.A Structure and Function
  • LS3.A Inheritance of Traits
  • LS3.B Variation of Traits
Cross Cutting Concepts
  • -
Science & Engineering Practices
  • -

Curriculum Resources

Lesson Plan
TtGG Laboratory Curriculum Overview

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Gene Sheets

Digital Download
ACE Gene Sheet

Download
Digital Download
ACTN3 Gene Sheet

Download
Digital Download
OXTR Gene Sheet

Download
Digital Download
CYP2C19 Gene Sheet

Download
Digital Download
TAS2R38 Gene Sheet

Download

Teacher Protocols

Digital Download
Micropipette Practice - Teacher Protocol

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Digital Download
DNA Extraction Long - Teacher Protocol

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Digital Download
DNA Extraction Quick - Teacher Protocol

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Digital Download
Polymerase Chain Reaction - Teacher Protocol

Download
Digital Download
Restriction Digest - Teacher Protocol

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Digital Download
Gel Electrophoresis - Teacher Protocol

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Digital Download
Prep for Sequencing - Teacher Protocol

Download
Digital Download
Sequence Analysis - Teacher Protocol

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Student Protocols

Digital Download
Micropipette Practice - Student Protocol

Download
Digital Download
DNA Extraction Long - Student Protocol

Download
Digital Download
DNA Extraction Quick - Student Protocol

Download
Digital Download
Polymerase Chain Reaction - Student Protocol

Download
Digital Download
Restriction Digest - Student Protocol

Download
Digital Download
Gel Electrophoresis - Student Protocol

Download
Digital Download
Prep for Sequencing - Student Protocol

Download
Digital Download
Sequence Analysis - Student Protocol

Download

Virtual Laboratory

Interactive
Genetic Variation Interactive

Watch interactive
On Demand Video
DNA Extraction Simulation

Watch simulation
Digital Download
DNA Extraction Infographic

View infographic
Interactive
PCR Interactive

Watch interactive
Digital Download
PCR Lab Protocol Infographic

View infographic
On Demand Video
Determining Genotypes Animation

Watch video
On Demand Video
Gel Electrophoresis Simulation

Watch simulation
Interactive
RFLP Interactive

Watch interactive
Digital Download
Prep for Sequencing Infographic

View infographic
Interactive
Sequencing Interactive

Watch interactive

Protocol Resources

On Demand Video
TtGG Protocols Video Playlist

Watch series
Digital Download
DNA Extraction Infographic

View infographic
Digital Download
Prep for Sequencing Infographic

View infographic

TtGG Sequence Files

Digital Download
ACTN3 Sequence Files

Download
Digital Download
CYP2C19 Sequence Files

Download
Digital Download
OXTR Sequence Files

Digital Download
TAS2R38 Sequence Files

Download

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