JAX-Sen refers to The Jackson Laboratory's (JAX) participation in the NIH’s Cellular Senescence Network (SenNet) Program. The JAX-Sen Mouse Tissue Mapping Center is led by Nadia Rosenthal, Ron Korstanje, and Paul Robson and is, like the KAPP-Sen Human Tissue Mapping Center in Farmington, a collaboration between JAX and UConn Health.
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. Senescent cells accumulate during aging and have been implicated in promoting a variety of age-related diseases. Cellular senescence may play an important role in tumor suppression, wound healing, and protection against tissue fibrosis; however, accumulating evidence that senescent cells may have harmful effects in vivo and may contribute to tissue remodeling, organismal aging, and many age-related diseases also exists.
The BAC applies a multitude of analytical modalities to selected tissues
The DAC combines robust computational capability with scalable and reproducible scientific workflows to develop and implement Network- wide open data and metadata standards.
The Administrative Core provides a strong oversight of project progress and nurture a culture of collaborative, dynamic scientific exchange within JAX-Sen.
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Zhao Y, Ansarullah, Kumar P, Mahoney JM, He H, Baker C, George J, Li S. Causal network perturbation analysis identifies known and novel type-2 diabetes driver genes. bioRxiv [Preprint]. 2024 May 26:2024.05.22.595431. doi: 10.1101/2024.05.22.595431. PMID: 38826370; PMCID: PMC11142180.
Hardy CC, Korstanje R. Aging and urinary control: Alterations in the brain- bladder axis. Aging Cell. 2023 Dec;22(12):e13990. doi: 10.1111/acel.13990. Epub 2023 Sep 22. PMID: 37740454; PMCID: PMC10726905.
SenNet Consortium. NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health. Nat Aging. 2022 Dec;2(12):1090-1100. doi: 10.1038/s43587-022-00326-5. Epub 2022 Dec 20. PMID: 36936385; PMCID: PMC10019484.