NSG-Flt3L-KO TSLP-KI-IL6-KI (NSGFT6) mice combine the features of the highly immunodeficient NOD scid gamma (NSG&trade;) mouse (Stock No. <a href="https://www.jax.org/strain/005557" target="_blank">005557</a>) with a mouse FMS-like tyrosine kinase 3 (Flt3) knock-out and knock-in/knock-outs of both the human interleukin 6 (IL6) gene and human thymic stromal lymphopoietin (TSLP) gene that support the stable engraftment of human hematopoiesis. These mice allow superior engraftment of diverse hematopoietic lineages and are useful for immune-oncology, immunology and infectious disease studies. Female mice are anticipated to better support human HSPC engraftment than males (see PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/20207983/" target="_blank">20207983</a> and PMID:<a href="https://pubmed.ncbi.nlm.nih.gov/26595075/" target="_blank">26595075</a>). Engraftment by males was not tested by the donating laboratory. SPF (specific pathogen-free) conditions are recommended. Please see our <a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/nsg-portfolio/housing-and-breeding-considerations-for-nsg-mice" target="_blank">NSG housing and breeding</a> information for additional details. View our <a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/nsg-portfolio">Resources for the NSG&trade; mouse model</a>, including: <ul><li>NSG&trade; Mouse Model Portfolio</li><li>Housing and Breeding Considerations for NSG&trade; Mice</li><li>Frequently Asked NSG&trade; Questions</li><li>Breakthrough Research Using NSG&trade;</li><li>Immunodeficient Mouse and Xenograft Host Comparisons</li><li>Flow Cytometry Characterization Data for Immunodeficient JAX Strains</li></ul>

The use of this mouse model is subject to the terms and conditions of the Limited Use Label License from Caribou Biosciences, Inc.

The use of this mouse strain or other product (the "Licensed Product") is subject to the terms and conditions of the Limited License from The Broad Institute.

Use of MICE by companies or for-profit entities requires a no-fee JAX Leap License prior to shipping.

NSG-Flt3L-KO TSLP-KI-IL6-KI (NSGFT6) mice combine the features of the highly immunodeficient NOD scid gamma (NSG&trade;) mouse (Stock No. <a href="https://www.jax.org/strain/005557" target="_blank">005557</a>) with a mouse FMS-like tyrosine kinase 3 (Flt3) knock-out and knock-in/knock-outs of both the human interleukin 6 (IL6) gene and human thymic stromal lymphopoietin (TSLP) gene that support the stable engraftment of human hematopoiesis. These mice allow superior engraftment of diverse hematopoietic lineages and are useful for immune-oncology, immunology and infectious disease studies. <a href="https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/humanized-mice">Please click here to order our Humanized Mice</a>.

Not available for ordering yet; register interest to be informed of changes in availability or <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support/technical-support/contact-technical-support-form">Contact Technical Support</a> for more information.

Homozygous for Il6<em1(IL6)Akp>, Homozygous for Flt3<em1Akp>, Homozygous for Prkdc<scid>, Homozygous for Tslp<em3(TSLP)Akp>, Homozygous for Il2rg<tm1Wjl>

Homozygous for Il6<em1(IL6)Akp>, Homozygous for Flt3<em1Akp>, Homozygous for Prkdc<scid>, Homozygous for Tslp<em3(TSLP)Akp>, Hemizygous for Il2rg<tm1Wjl>