Partner with The Jackson Laboratory for a suite of Alzheimer's disease (AD) models and services that reliably recapitulate clinical features of human AD, including β-amyloid plaques, tau pathology, neuroinflammation, neurodegeneration and cognitive dysfunction, with demonstrated translational relevance.
JAX's portfolio of translatable AD models is detailed below, organized by key pathological targets to help you identify the best model for your research.
Advancing Alzheimer's disease therapeutics requires the right models and the right partner. Our dedicated study directors work closely with sponsors to design and execute studies using relevant and translatable AD models. Backed by JAX's expertise in mouse genetics and in vivo model characterization, we are here to facilitate your drug development goals.
Available biomarker endpoints include:
| Study Design | Detail |
|---|---|
| Model | |
| Timeline | 9 weeks |
| Groups | n=12 per group, 5 groups |
| In Vivo | Daily Dosing for 8 weeks or ONE neonatal or adult ICV injection. Weekly:
Other:
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| Ex Vivo |
|
Biomarkers in 5XFAD and PS19 mice are more reliable and reproducible than behavioral assays.
PS19 008169, Males, 6 months of age.
Non-transgenic wild type mice (NCAR) display the natural preference for the novel object while PS19 transgenics (HEMI) do not, an indication that they may not remember the previous encounter with the familiar object.
PS19 008169
Phospho-Tau can be detected by WES analysis at 9 months (and as early as 3 months) in PS19.
5XFAD 006554
Beta-amyloid can be detected by Immunoassay at 9 months in 5xFAD.
For each mouse model the entire mouse gene is replaced with the corresponding human gene under endogenous regulatory control.
These models have been shown to be useful for testing genetic risk factors and evaluating the effect of aging and environmental factors, such as traumatic brain injury and high-fat diet.
This APPSAA knock-in model recapitulates clinical amyloid plaque pathology in vivo without disturbing intrinsic gene expression. There are no licenses or restrictions on commercial use.
